Anti-LPA Recombinant Antibody (LT3015 [B7(LT3000, Lpathomab)]) (CAT#: TAB-0340CL)
This humanized antibody LT3015 is generated from the high-affinity, specific anti-LPA mouse mAb LT3000, also called Lpathomab. The target of the antibody lysophosphatidic acid is a bioactive lipid mediating multiple cellular responses, and it's involved in the establishment and progression of cancer by providing a pro-growth tumor microenvironment and promoting angiogenesis. The EC₅₀ of the humanized antibody to 12:0 (lauroyl) LPA was determined to be 75.6 ng/mL by ELISA.
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Figure 1 LPA binding affinity measured as in Figure for native LT3015 (WT) and three LT3015 single point mutations.
Fleming, J. K., Wojciak, J. M., Campbell, M. A., & Huxford, T. (2011). Biochemical and structural characterization of lysophosphatidic Acid binding by a humanized monoclonal antibody. Journal of molecular biology, 408(3), 462-476.
Figure 2 Site-directed mutagenesis and LPA binding assays of LT3015.
In comparison to native LT3015 (WT), the introduction of mutations in the LT3015 heavy chain (AsnH52Tyr/SerH52Tyr) or light chain (AnsL30Arg) does not significantly increase LPA affinity. However, their combination (AsnH52Tyr/SerH54Tyr/AsnL30Arg) results in a modified version of the antibody with increased LPA binding affinity.
Fleming, J. K., Wojciak, J. M., Campbell, M. A., & Huxford, T. (2011). Biochemical and structural characterization of lysophosphatidic Acid binding by a humanized monoclonal antibody. Journal of molecular biology, 408(3), 462-476.
Specifications
- Host Species
- Human
- Type
- Humanized Antibody
- Clone
- LT3015 [B7(LT3000, Lpathomab)]
- Related Disease
- Macular degeneration, pain-related disorders, malignancies, angiogenesis, fibrosis-related disorders
Target
- Alternative Names
- LPA; Lysophosphatidic acid
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-329 | Recombinant Human Anti-S. aureus LPA Antibody | WB, ELISA, FuncS | IgG |
| ZG-0295F | Mouse Anti-LPA Recombinant Antibody (ZG-0295F) | WB, IHC, ELISA | Mouse IgG |
| VS3-XY1017 | Mouse Anti-LPA Recombinant Antibody (clone 4H1) | ELISA, WB, IHC, ICC | Mouse IgG1 |
| VS7-0425-WR305 | Mouse Anti-LPA Monoclonal Antibody (clone 8F6A9) | IHC | Mouse IgG1 |
| VS7-0425-WR306 | Mouse Anti-LPA Monoclonal Antibody (VS7-0425-WR306) | WB, IHC-P, IF, ELISA | Mouse IgG |
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To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-0340CL, RRID: AB_3111766)
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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